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However, since they are not FDA-approved, there's less known about their long-term safety and effectiveness
While the prescribing information for GLP-1 medications does not specifically list Crohn's disease as a contraindication, the Summary of Product Characteristics (SmPC) for these medicines does advise caution in patients with gastrointestinal disease and states they are not recommended in severe gastrointestinal disease
Graphical Abstract Highlights Diabetes mellitus (DM) is emerging as a serious global health issue
It was concluded that the C max and AUC changes of digoxin after GLP-1 RA administration may not be clinically significant
PLoS ONE 6 , e19194 (2011)
Biol 56, 229242 (1976)
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